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CHEMBRDG-BB 5280909

Product Name
CHEMBRDG-BB 5280909
CAS No.
89159-60-4
Chemical Name
CHEMBRDG-BB 5280909
Synonyms
ML-354;CHEMBRDG-BB 5280909;1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol;1H-Indole-2-methanol, 1-methyl-5-nitro-3-phenyl-;(1-METHYL-5-NITRO-3-PHENYL-1H-INDOL-2-YL)METHANOL;(1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol(SALTDATA: FREE)
CBNumber
CB9163102
Molecular Formula
C16H14N2O3
Formula Weight
282.29
MOL File
89159-60-4.mol
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CHEMBRDG-BB 5280909 Property

Melting point:
178-179 °C(Solv: 1,4-dioxane (123-91-1))
Boiling point:
544.0±50.0 °C(Predicted)
Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
-20°C
solubility 
≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
pka
14.47±0.10(Predicted)
form 
powder
color 
white to beige
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Safety

RIDADR 
UN 2811 6.1 / PGIII
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

Precautionary statements

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Cayman Chemical
Product number
19120
Product name
ML-354
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
19120
Product name
ML-354
Purity
≥95%
Packaging
5mg
Price
$86
Updated
2024/03/01
Cayman Chemical
Product number
19120
Product name
ML-354
Purity
≥95%
Packaging
10mg
Price
$146
Updated
2024/03/01
Cayman Chemical
Product number
19120
Product name
ML-354
Purity
≥95%
Packaging
25mg
Price
$343
Updated
2024/03/01
Tocris
Product number
5387
Product name
ML354
Purity
≥98%(HPLC)
Packaging
10
Price
$149
Updated
2021/12/16
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CHEMBRDG-BB 5280909 Chemical Properties,Usage,Production

Description

ML-354 is an indole-based, proteinase-activated receptor 4 (PAR4) antagonist (IC50 = 140 nM) that exhibits 71-fold selectivity for PAR4 over PAR1 (IC50 = 10 μM) in isolated human platelets.

Uses

ML-354 is a selective protease activated receptor 4 ( PAR-4) antagonist used for its antithrombotic effects.

Biochem/physiol Actions

ML354 is a potent and selective PAR4 (protease activated receptor-4) antagonist.

IC 50

140 nm

storage

Store at -20°C

References

[1]. wen, w., young, s., duvernay, m., schulte, m., nance, k., & melancon, b. et al. substituted indoles as selective protease activated receptor 4 (par-4) antagonists: discovery and sar of ml354. bioorganic & medicinal chemistry letters. 2014; 24(19): 4708-4713.

CHEMBRDG-BB 5280909 Preparation Products And Raw materials

Raw materials

Preparation Products

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CHEMBRDG-BB 5280909 Suppliers

China 26 United Kingdom 1 United States 7 Global 34
Aladdin Scientific
Tel
+1-833-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
52927
Advantage
58

89159-60-4, CHEMBRDG-BB 5280909Related Search:

5-AMINO-2-METHYLINDOLE 2,3-DIMETHYL-5-NITROINDOLE 2-METHYL-5-NITROINDOLE 2-methyl-3-phenyl-1H-indole 3-phenylindole (1-METHYL-1H-INDOL-2-YL)-METHANOL 5-AMINO-2,3-DIMETHYLINDOLE ETHYL 6-TERT-BUTYL-2-METHYLNICOTINATE 5-AMINO-1-N-METHYLINDOLE 1-METHYL-5-NITRO-1H-INDOLE CHEMBRDG-BB 5280909

  • CHEMBRDG-BB 5280909
  • (1-METHYL-5-NITRO-3-PHENYL-1H-INDOL-2-YL)METHANOL
  • (1-methyl-5-nitro-3-phenyl-1H-indol-2-yl)methanol(SALTDATA: FREE)
  • ML-354
  • 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol
  • 1H-Indole-2-methanol, 1-methyl-5-nitro-3-phenyl-
  • 89159-60-4